Wondering if anyone can help.

Mrs Bother has been running for about 2 years now, but after a couple of mile or so she gets intense pain on the balls of her feet, right at the front near her toes and has to stop till it eases, they usualy go tingly and numb and then she can hobble home.
She runs on her forefoot rather than rolling from heel to toe, we have tried various types of shoe but to no avail.

Many years ago she said she could never wear "clarks" type shoes for walking as she had the same problem, more recently she is getting general numbness in the same area when cycling or even walking about.