Originally Posted by
Feet In The Cloughs
The August 2020 date refers to the search point start for this meta analysis (of global studies) and includes phase III clinical trials prior to mass public vaccination and these were not included in the work but some were used to compare vaccine effectiveness given in trials with ‘real world’ vaccine delivery.
The final two paragraphs of the paper are instructive:
‘Studies in the real-world setting around the world have shown that the approved vaccines are highly protective against SARS-CoV-2; therefore, the aim should be full vaccination according to the standard schedule to achieve maximum VE. It is worth noting that vaccination cannot eliminate the risk of infection (Brosh-Nissimov et al., 2021), and preventive and control measures should be taken seriously, especially for high-risk groups.
In conclusion, consistent with the results of phase III clinical trials, the authorized vaccines are highly protective against SARS-CoV-2 in real-world settings. Furthermore, the actual VE depends not only on the effectiveness of the vaccine itself but also on the vaccinated population and status. Preventive measures remain essential’ (Zheng et al. 2022).
Zheng C, Shao W, Chen X, Zhang B, Wang G, Zhang W. Real-world effectiveness of COVID-19 vaccines: a literature review and meta-analysis. Int J Infect Dis. 2022 Jan;114:252-260. doi: 10.1016/j.ijid.2021.11.009. Epub 2021 Nov 17. PMID: 34800687; PMCID: PMC8595975.