Quote Originally Posted by ZootHornRollo View Post
I think Updownupdown might be being a tad alarmist here about the terrible consequences of Ibupe and diclofenac. Saying they 'cause renal failure' and 'cause ulcers and gastritis' without massive qualifications is just misleading. Where's the empirical evidence to back all this up?

The vast majority of people who take these anti-inflamms have no side-effects whatsoever. Taken properly they pose virtually no problems to anyone. Most people aren't daft enough to take large amounts on empty stomachs and get dehydrated.

I wasn't aware that Ibupe can prevent cramp, but glad to hear it does.
I agree I'm somewhat alarmist, the risks are relatively low. Not sure I'd say it's actually misleading. There is good evidence, you are quite reasonably querying the incidence of harmful effects though.

For GI bleeding an NSAID user has about 4x the risk of a non user, however this is based on pooled studies it's dose and drug related, and if you're young and healthy its lower, if you're old and have bled previously it's masses higher, and that's still a low risk of course as a non users GI bleeding risk is only 1 per 1000 person years. Evidence since you ask: Association Between Nonsteroidal Anti-inflammatory Drugs and Upper Gastrointestinal Tract Bleeding/Perforation
An Overview of Epidemiologic Studies Published in the 1990s Sonia Hernández-Díaz, MD, MPH; Luis Alberto García Rodríguez, MD, MSc
Arch Intern Med. 2000;160:2093-2099.

Renal issues; probably easiest to look at here if you really want:http://www.cks.library.nhs.uk/nsaids...nsider#-330673

And being pedantic they do not prevent cramp, they would be expected to reduce the pain of cramp as they are painkillers.

Actually I wish I'd never mentioned it,