Isn't Advan-tic is a spot that should prevent ticks from staying on the dog, but not a vaccine. A specific Lyme disease vaccine for dogs is now available though: http://www.lymeinfo.com/prevent-Lyme/vaccination.html

I got a vaccine to prevent diseases carried by ticks when I grew up in Austria - but it does not protect from Lyme disease (http://zecken.at/schutzimpfung/impfstoff/ for those who speak German)